Main use-cases | estimate haplotype frequencies |
Authors | Xiaohong Li |
Latest version | NA |
Code repository | https://cran.r-project.org/src/contrib/Archive/malaria.em/ |
Publication | https://doi.org/10.2202/1544-6115.1321 |
malaria.em
Summary sheet
Purpose
Program designed to discern the combinations of mutations at the population level to estimate frequencies of these clonal sequences. This program utilizes an expectation maximization (EM) approach to maximum likelihood estimation of haplotype frequencies from the SNP loci per sample information.
The code for this program was removed from CRAN in 2014 and does not appear to be activiely maintained. A program that does something similar is MultiLociBiallelicModel.
Citation
References
Li, Xiaohong, Andrea S Foulkes, Recai M Yucel, and Stephen M Rich. 2007. “An Expectation Maximization Approach to Estimate Malaria Haplotype Frequencies in Multiply Infected Children.” Stat. Appl. Genet. Mol. Biol. 6 (November): Article33.