THE REAL McCOIL

Author

Nick Brazeau

Published

December 12, 2023

Summary sheet

Main use-cases	Estimation of complexity of infection
Authors	Hsiao-Han Chang
Latest version	NA
License	NONE
Website	https://github.com/EPPIcenter/THEREALMcCOIL
Code repository	https://github.com/EPPIcenter/THEREALMcCOIL
Publication	https://pubmed.ncbi.nlm.nih.gov/28125584/
Tutorial authors	Nick Brazeau
Tutorial date	Dec 12 2023

Purpose

THE REAL McCOIL is a method for estimating the complexity of infections within a malaria-infected host, where complexity of infection (COI) is defined as the number of distinct genotypic parasites within the host. This tutorial focuses on the categorical method for estimating COI.

Existing resources

Chang, HH et al. 2017, PLoS Comp Biol

Citation

Chang HH, Worby CJ, Yeka A, Nankabirwa J, Kamya MR, Staedke SG, Dorsey G, Murphy M, Neafsey DE, Jeffreys AE, Hubbart C, Rockett KA, Amato R, Kwiatkowski DP, Buckee CO, Greenhouse B. THE REAL McCOIL: A method for the concurrent estimation of the complexity of infection and SNP allele frequency for malaria parasites. PLoS Comput Biol. 2017 Jan 26;13(1):e1005348. doi: 10.1371/journal.pcbi.1005348. PMID: 28125584; PMCID: PMC5300274.