Forwards-in time simulation of Plasmodium falciparum genetic data can be computationally intensive, as many genotypes are tracked but ultimately lost. SIMPLEGEN avoids this problem by splitting simulation into three steps - first, simulating transmission under a simple individual-based model, second, pruning the infection history to focus on nodes that contribute to the final sample, and third, simulating genetic data. A secondary advantage is that any third-party epidemiological simulator can be used for the first step as long as it outputs in the correct format. The major limitation of SIMPLEGEN is that assumes the epidemiological and genetic processes are seperable, and hence is limited to neutral variation, and cannot model selection.