### Installing Rcpp

SIMPLEGEN relies on the Rcpp package, which requires the following OS-specific steps:

• Windows
• Download and install the appropriate version of Rtools for your version of R. On installation, ensure you check the box to arrange your system PATH as recommended by Rtools
• Mac OS X
• Within XCode go to Preferences : Downloads and install the Command Line Tools
• Linux (Debian/Ubuntu)
• Install the core software development utilities required for R package development as well as LaTeX by executing

sudo apt-get install r-base-dev texlive-full

Next, in R, ensure that you have the devtools package installed by running

install.packages("devtools", repos='http://cran.us.r-project.org')

Then install the SIMPLEGEN package directly from GitHub by running

devtools::install_github("mrc-ide/SIMPLEGEN")

If you have any problems installing, please raise an issue on github.

Assuming everything installed correctly, we need to load the package:

library(SIMPLEGEN)

You can test that the package is loaded and working by running the following command, which should produce the following output:

check_SIMPLEGEN_loaded()
## SIMPLEGEN loaded successfully!