Malariasimulation Workshop Introduction

Welcome all!

Today’s aims:

  • Provide a broad overview of malariasimulation
  • Learn how to run the model, view and plot model outputs
  • Introducing interventions
    • Treatment
    • Bednets
    • Other interventions

Not today’s aims 😄

  • An introduction to the Imperial college malaria model
    • Please see key publications
  • An introduction to the software package used to create the model
    • 📦[individual]
    • Please see websites and supporting documentation for help
  • Context-specific modelling

malariasimulation, individual, ODE model

What is 📦[malariasimulation]

Malariasimulation is a individual-based, mechanistic, dynamic malaria transmission model.

We model each human as an individual in the modelled population

We try to simulate the actual processes and interactions associated with malaria transmission

Many aspects of the modelled system change over time

Malariasimulation structure

Malariasimulation captures the environment, the mosquito population and the human population

Malariasimulation structure

Intervention modules can be include to capture the impact of malaria prevention and control

Malariasimulation fitting and validation

Malariasimulation has been extensively fitted and validated against data to capture observed relationships between key metrics and the impact of interventions.

Griffin et al 2010, White et al 2011, Griffin et al 2014, Griffin et al 2015, Griffin et al 2010, Griffin et al 2010

Malariasimulation and context specific modelling

  • 📦[malariasimulation] is a “generic” Plasmodium falciparum malaria model
  • Running and exploring model outputs for generic settings is helpful to learn how to run the model, what to expect from the output and how changing parameters influences model results.
  • Often, we want to apply the model to a specific setting (e.g. a country, a trial site).
  • Context specific runs are more complex and require lots of specific input data. We have software pipelines to support this work (contact Pete Winskill for more information).

Let’s give it a try!

  • 📦 [malsimtutorial] has interactive tutorials. You can run code within the tutorial window (or in R/Rstudio if desired).
  • Run malsimtutorial::run_tutorial("Introduction")